swapnil hiremath

November 24, 2020

Background

Belimumab and Lupus Nephritis: A Marriage made by B Cells?

swapnil hiremath

November 24, 2020

Background

Belimumab and Lupus Nephritis: A Marriage made by B Cells?

This is the first, yes, the first time we are discussing a trial in SLE patients. Belimumab, which inhibits BAFF also called BLyS (hence the BLISS trials) in lupus nephritis. Added to a background of standard therapy - what does it give us? Let’s dive in.

swapnil hiremath

November 9, 2020

Background

Can Finerenone Fiddle the Forgotten A of the RAAS String?

swapnil hiremath

November 9, 2020

Background

Can Finerenone Fiddle the Forgotten A of the RAAS String?

This week, we will discuss whether the time has come to add mineralocorticoid antagonism to the RAS armamentarium. Can we surmount the hyperkalemia which is the commonest problem with these drugs? Let’s find out with FIDELIO.

swapnil hiremath

October 20, 2020

Background

Diabetes and the Kidney

swapnil hiremath

October 20, 2020

Background

This week, we will discuss the fresh-off-the-press KDIGO guidelines on Diabetes. RAS Blockade and SGLT2i, needless to say - but is there more? There is. Read on as we break it down for you.

swapnil hiremath

October 4, 2020

Background

Dapperly Gliding into the Nondiabetic Arena

swapnil hiremath

October 4, 2020

Background

Dapperly Gliding into the Nondiabetic Arena

SGLT2 inhibitors lower MACE in Diabetes. Then they decrease kidney failure in DM. Then Heart Failure in DM and non-DM. And now decrease kidney failure in nonDM too! Let’s see how strong the data really is

joel topf

September 22, 2020

Background

Fluid restriction for SIADH has to work. Doesn't it?

joel topf

September 22, 2020

Background

Fluid restriction for SIADH has to work. Doesn't it?

This week, we discuss an RCT that tests if fluid restriction even works in SIAD.

swapnil hiremath

September 8, 2020

Background

Can drug coating pop the balloon of dysfunctional dialysis access?

swapnil hiremath

September 8, 2020

Background

Can drug coating pop the balloon of dysfunctional dialysis access?

This week, we will discuss an unusual feature in nephrology: a trial in NEJM from nephrology that is positive. And on vascular access at that!

swapnil hiremath

August 24, 2020

Background

Rana Awdish's In Shock

swapnil hiremath

August 24, 2020

Background

Its book club time! We will be discussing Rana Awdish’s bestseller, the searing first person narrative of a doctor going through a critical illness. And almost dying.

swapnil hiremath

August 18, 2020

Background

Albuminuria = Proteinuria, Sorta?

swapnil hiremath

August 18, 2020

Background

This week, we will review the herculean task from the authors of the Annals paper, which examines whether PCR is just as good as ACR.

swapnil hiremath

August 4, 2020

Background

Time to Stop Starting RRT Early in AKI

swapnil hiremath

August 4, 2020

Background

This week, we will discuss the fresh-off-the-press STARRT AKI trial. The final, definitive trial to let us know about the timing of KRT in the ICU.

joel topf

July 14, 2020

Background

The Future is Now: Social Media in Seminars

joel topf

July 14, 2020

Background

The Future is Now: Social Media in Seminars

This week, we will discuss the social media issue in Seminars of Nephrology. The discussion will be anchored by two articles - but the whole issue is up for discussion.

swapnil hiremath

June 30, 2020

Background

Correlation is Confusion not Causation: The Case of Uric Acid in CKD

swapnil hiremath

June 30, 2020

Background

Correlation is Confusion not Causation: The Case of Uric Acid in CKD

This week, we will discuss the fresh-off-the-press trials from this week’s issue of the NEJM: PERL and CKD-FiX. These two trials examined if the uric acid and CKD link is causal: by measuring CKD progression after giving patients allopurinol. Be ready for another medical reversal.

swapnil hiremath

June 16, 2020

Background

Diagnosing Aldosteronism

swapnil hiremath

June 16, 2020

Background

This week, we will discuss the correct way to diagnose primary aldosteronism. Is a spot ARR sufficient? Prepare to turn whatever you thought you knew about PA around.

swapnil hiremath

May 26, 2020

Background

SGLT2 inhibitors: Sweet (and Salty) Pee

swapnil hiremath

May 26, 2020

Background

SGLT2i are the wonder drug for our age. But do we know how they work? How does their natriuretic effect actually work? Let’s dig deeper into this week’s mechanistic study that explores this question

Guest User

May 11, 2020

Background

No Pain for the Kidneys from NSAIDs

Guest User

May 11, 2020

Background

This week, we discuss the latest from CRIC, an examination of NSAIDs versus opioids for patients with CKD. Join us May 12 and 13th to discuss with #NephJC.

swapnil hiremath

April 27, 2020

Background

Renalism Returns

swapnil hiremath

April 27, 2020

Background

This week, we will not discuss anything related to COVID. We know cardiovascular disease is the cause of most morbidity and mortality in CKD. Can an invasive approach benefit our patients?

swapnil hiremath

April 14, 2020

Background

COVID in the Kidney: An Autopsy Series

swapnil hiremath

April 14, 2020

Background

This week, as an emergency chat, we will discuss some hot-off-the-press data. Published a few days ago, the first look at what happens in the kidneys.

swapnil hiremath

April 6, 2020

Background

Minimal Role for Steroids in Minimal Change Disease?

swapnil hiremath

April 6, 2020

Background

Minimal Role for Steroids in Minimal Change Disease?

Steroids are the mainstay of minimal change. Or are they? Lets explore an RCT that bravely challenges the status quo of steroids with tacrolimus monotherapy

Guest User

March 9, 2020

Background

ISPD Practice Recommendations 2020 - From ‘Patient’ to ‘Person’

Guest User

March 9, 2020

Background

ISPD Practice Recommendations 2020 - From ‘Patient’ to ‘Person’

This week, we will discuss the fresh-off-the-press ISPD recommendations on what they call as ‘prescribing high quality, goal directed’ PD. No mention of adequacy even in the title, in a subtle shade at the move away from numbers to things that really matter.

swapnil hiremath

February 24, 2020

Background

perPLEXed by ANCA? Let PEXIVAS show you the path to less steroids and the end of plasma exchange

swapnil hiremath

February 24, 2020

Background

perPLEXed by ANCA? Let PEXIVAS show you the path to less steroids and the end of plasma exchange

This week we discuss the long awaited PEXIVAS trial. Reduced dose steroids win, and PLEX loses. Or does it?

swapnil hiremath

February 11, 2020

Background

Are ANCA actually attackers?

swapnil hiremath

February 11, 2020

Background

We are now in GN territory this month - or rather ANCA Vasculitis month! First we start off with this paper from London, which uses some data from the RAVE trial along with additional experiments to show some intriguing results on the role of MPO.