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🤔 Epo production in kidneys
The transcriptional and regulatory identity of erythropoietin producing cells (Kragesteen, Nature Medicine 2023)
🤔 Glucose absorption drives cystogenesis in PKD
Glucose absorption drives cystogenesis in a human organoid-on-chip model of polycystic kidney disease (Li, Nature Communications 2023)
The Kidney Cellular Architecture Atlas
The kidney cell architecture atlas infographic by Dr Jithu Kurian
Role of mRNA cis-inhibition in PKD progression
CHIPping away at Kidney Disease
Figuring out fibrosis
Are ANCA actually attackers?
Autosomal Dominant Tubulointerstitial Kidney Disease: Current Challenges and Future Opportunities
Can We Stop MUC-1 From Mucking Up the Kidney
Some cases of ADTKD are due to mutations of the MUC-1 gene, one mutation is a frame shift mutation that results in a premature stop codon. which results in accumulation of the abnormally short, and toxic protein MUC-1 fs . The researchers found a small protein, BRD4780, that reroute MUC-1fs to lysosomes, preventing proteinopathy and possibly altering the natural history of the disease.