Blog — NephJC

RCT

ADVOR TRIAL - Can the addition of a little buddy make a big difference ?

ADVOR TRIAL - Can the addition of a little buddy make a big difference ?

This week, we will discuss The ADVOR trial, possibly the only randomized, placebo controlled trial of sequential nephron blockade ever. Could the use of acetazolamide in acute decompensated heart failure make a difference?

Correlation is Confusion not Causation: The Case of Uric Acid in CKD

Correlation is Confusion not Causation: The Case of Uric Acid in CKD

This week, we will discuss the fresh-off-the-press trials from this week’s issue of the NEJM: PERL and CKD-FiX. These two trials examined if the uric acid and CKD link is causal: by measuring CKD progression after giving patients allopurinol. Be ready for another medical reversal.